감염성 심내막염에 이환되기 쉬운 소아에서 구강내 세균총에 대한 항균제 감수성 연구

A STUDY ON THE ANTIMICROBIAL SUSCEPTIBILITY OF ORAL MICROFLORA IN CHILDREN SUSCEPTIBLE TO INFECTIVE ENDOCARDITIS

The present study has been performed to evaluate 20 cardiopathy children and 20 healthy children s oral micorbes at the point of antimicrobial susceptibilities for antimicrobial prophylaxis to prevent bacterial endocarditis. The results were as follows : 1. Both groups had similar oral microbes. 2. The antimicrobial susceptibility of S. viridans were: Penicillin＜ Oxacillin＜ Ampicillin＜ Cephalothin＜ Erythromycin＜ Clindamycin＜ Gentamicin＜ Ciprofloxacin＜ Vancomycin=Imipenem. The cardiopathy group was slightly lower antimicrobial susceptibility rates than healthy group. 3. The antimicrobial susceptibility of Neisseriaceae were: Clindamycin＜ Erythromycin＜ Vancomycin＜ Penicillin＜ Gentamicin＜ Cephalothin＜ Ciprofloxacin＜ Imipenem. The antibiotics of bacterial endocarditis antibiotic prophylaxis regimens for dental procedures according to the American Heart Association were generally lower antimicrobial susceptibilities, so they were considered inadequate for the first selective antibiotics and Imipemem was best suitable antimicrobials. Conclusively, when choose antimicrobials for treatment or antimicrobial prophylaxsis for bacterial endocarditis, surveillant culture must be performed to evaluated personal antimicrobial susceptibilities of intraoral microbes for proper antimicrobial choice for dental procedures.