고삼 에탄올과 열수추출물의 항산화, 항염증 및 항균효과

Antioxidant, antiinflammatory and antimicrobial activity of Sophora flavescens ethanol and hydrothermal extracts

This study comparatively reviewed the antioxidant, antiinflammatory and anti-microbial effects of Sophora flavescens extracts. As a results of DPPH free radical, ethanol and hydrothermal extracts were 60.01% and 31.77%, respectively, at 500 μg/mL. Therefore, the former was higher in scavenging activity in a dependent fashion. Total polyphenol and flavonoid contents of the ethanol extract were 71.84 ±14.95 and 42.32 ± 1.05 μg/mL, respectively, while the hydrothermal extract was 61.20 ±2.35 and 35.80 ±4.79 μg/mL, respectively. Toxicity of ethanol extracts on HaCaT cells, no cytotoxicity was found at 10 μg/mL. In addition, concentration-dependent protective effects were verified for the oxidative stress caused by H₂O₂. Antimicrobial activity of ethanol extracts against skin flora such as Staphylococcus epidermidis, Staphylococcus aureus and Propionibacterium acnes were observed. a clear zone was observed in the ethanol strain. In Malassezia furfur, in contrast, antimicrobial inhibitory activity was detected in hydrothermal extracts as well. The said results show that the ethanol extract is greater than the hydrothermal extract in terms of antimicrobial, anti-inflammatory and antioxidant activities.