항섬유소용해제의 국소 적용이 발치후 지혈 및 창상 치유에 미치는 효과

The effect of antifibrinolytic agent on postextraction wound healing

The objective of the present clinical investigation was to examine the effects of local antifibrinolytic treatment on normal postextraction bleeding control, healing and following complications, with 5%tranexamic acid gargle solution which is a well known alternative to blood product therapy for dental extractions in the mild to moderate haemophiliac patient and to risky anticoagulant dose reduction in patients with various cardiovascular problems. The study compared 40 cases of healthy patients divided into two groups of placebo-controlled and experimental. The control side was treated with normal saline, whereas in the experimental side, the local antifibrinolytic treatment with 5% tranexamic acid gargle solution was given with following method : before suturing or gauze biting, the extracted socket was irrigated with 10 ml of 5% aqueous solution of tranexamic acid and followed by tranexamic acid impregnated gauze biting for 20 minutes. For seven days thereafter, patients were instructed to rinse their mouth with 10ml of the gargle solution for two minutes four times a day. It was concluded that postextraction bleeding control and wound healing was taster and more uneventful with less complications in the group treated with 5% tranexamic acid gargle solution than normal saline treated placebo control group. Therefore, local application of 5% tranexamic acid gargle solution is suggested to be recommendable as a routine postextraction treatment.