백서 두개골에 형성된 골 결손부 크기에 따른 골 치유과정에 대한 조직학적 연구

Histologic study of healing process of different size calvarial defect in rats

The author made calvarial defects of different sizes in rat to study the effect of defect size on healing process. Experimantal animals were sacrified at 3 days, 1 week, 2, 4, 6 weeks. The specimens were examed under light microscope with Hematoxlin-Eosin and modified Gomori s trichrome stain, and under fluorescent microscope after glinding the specimens. The results were as follows. 1. 4mm-diameter calvarial defects healed about 70% after 6 weeks. 2. Lamellated bone trabecules were seen in 6mm-diameter calvarial defects after 4 weeks, and the small specules of bone and marrows were observed after 6 weeks. 3. 10mm-diameters calvarial defects healed about 50% and incomplete interconnection of the lamellated bone trabecules were observed after 6 weeks. 4. Under fluorescent microscope, about 4mm-long bone regeneration could be seen in most of the defects.