Streptozotocin으로 유도된 당뇨 백서와 비당뇨 백서에서 발치와의 치유과정에 관한 실험적 연구

An experimental study on the healing of extration socket streptozotocin-induced diabetic rats

The healing effect of D. M. on fracture, wound, extraction socket, oral soft tissue been studied. In recent studies, Glickman researched about the hew bone formation in periodontal disease under D. M. streptozotocin, used as D. M. inducer in experimental animals, has been used as broad spectrum antibiotics, anticancer drugs and carcinogen since 1960 years. Interestingly nowadays strepoozotocin in use to make the experimental diabetic animal model. Following microscopic examination of healing of extraction sockets in no-diabetic rats and that of streptozotocin induced diabetic rats. The results were as follows: 1. Trabecular formation consisting of osteoid could be seen in extraction sockets in control group(nondiabetic rats) after 1 week. 2. More chronic inflammation and less granulation tissue were seen in experimental group than control group after 1 week. 3. Trabecular pattern was seen after 4 weeks in experimental group. Trabecular pattern in control group was seen from 2 weeks specimen and became hardened after 4 weeks. 4. Experimental group showed delayed revascullarization, poor granulation tissue formation and incomplete trabecular formation. So it is suggested that D. M. has much more adverse effect on the healing process of the extraction sockets.