유도당뇨백서에 매식된 수산화인회석의 조직반응

Histologic response to hyydroxyapatite implantation in induced diabetic rats

The purpse of this study was to evaluate the tissue reaction to hydroxyapatite(HA) in rats given streptozotocin(50mg/kg) to incuce diabetics. A pocket was created on the parietal bone of cranium. 40 rats were divided: 20 induced diabetics (ID) with HA, 20 non-induced diabetics with HA used as control group. Rats from each group were sacrificed at 1, 2, 4, 8, 24 weeks post-implantation. The results of this study were a follows: 1. Inflammatory reaction of ID was more intense than ND at 1 and 2 weeks. 2. Fibrosis in control group was greater than ID, but no significant difference between 2 and 4 weeks after implantation. 3. Dystrophic calcification was no significant difference between ID and control group. 4. No osteogenesis was obseved in both groups. In conclusion, it is important to control the infection at 1 to 2 weeks after the HA implantation and if the infection is controlled, HA in our study was acceptable in both ID rats and ND controls, as inert material, because no osteogenesis was observed in any specimen.