조직접착제가 가토 피부창상 치유과정에 미치는 영향에 관한 실험적 연구

Experimental study of the effects of fibrin adhesive on wound healing process in rabbits

This experimental study was designed to investigate the wound healing process treated with fibrin adhesive is the dorsum of 12 rabbits. Fibrin adhesive which acts on the final phase of blood coagulation in wound healing process have increasingly been use and applied to the free skin grafting wounds and incisional surgical wounds to compare both conventional wound cares. In each experimental groups were sacrified at 1, 2, 3, 5, 7, 14days postoperatively and specimens have made as a usual methods. The results were as follows: 1. Initial hemorrhagic coagulation was prominent in the experimental groups and degree of inflammatory cell infiltrations, however, was marked as even in each groups. 2. Early fibroblast and new capillary proliferation were incorporated intensely with wound sites in the experimental groups. 3. By applying the tissue adhesive to wound sites, the initial healing process for closing in grafting operation was faster than the incisional surgical wound.