고압산소요법이 DMBA 유도백서 악하선암 발생에 미치는 영향에 관한 실험적 연구

Experimental study on the effect of hyperbaric oxygen therapy on the DMBA induced submaxillary gland carcinogenesis in albinorats

Oral cancer comprised about 5% of all cancer sin human body, the site of its origin is very complex and very important both cosmetically and functionally, thus the tratment, functional and cosmetic reconstructions are very difficult. In cancer patient, irradiation therapy is one of the choic among sevveral treatment methods, the hyperbaric oxygenation is utilized for the good wound healing following surgical procedure and bone reconstruction as well. Usually, many cancer patients are affected by the environment of hyperbaric oxygenation during irradiation therapy for better treatment results. On the other hand, it is controvertial about the effetiveness of oxygen therapy on carcinogenesis, some are effective, the others are non - effective. Therefore, the main objective of this study was focussed on the effectiveness of hyperbaric oxygenation therapy on the DMBA induced carcinogenesis in albino rats. After the observation of macroscopic and microscopic pathologic findings, the author has been able to arrive at the following conclusions. 1. All the chemically induced cancer was sqamous cell carcinoma. 2. The palpation of cancer in the experimental group has been possible after 8 weeks and this was 2 weeks earlier thar in control group, size of the mass in experimental group disclosed somewhat larger untill 11th week but, after that the difference in size between two groups has not been comparable. 3. During the initial period of inflammation caused by implantation of DMBA, the incidence of squamous metaplasia in experimental group showed higher incidence than in control group. 4. The epithelial dysplasia was found at th 17th day of experiment in both groups. 5. At the microscopic findings, development of cancer in experimental group was found 2 weeks earlier than in control group. It was considered that hyperbaric oxygenation has no effect of suppression on the carcinogenesis, but slight stimulating effect.