방사선 치료후 구강점막에 발생된 악성섬유조직구종

Postirradiation malignant fibrous histiocytoma(MFH) of the Oral mucosa -a case report-

Postirradiation sarcomas can be occurred after a long latent period following radiation therapy. The most frequent histologic type was reported as osteosarcoma, followed by malignant fibrous histiocytoma, lymphangiosarcoma. Despite the extensive use of high - dose radiation, postirradiated sarcomas are rarely developed on the head and neck region. This reports present a case of postirradiation malignant fibrous histiocytoma. The patient, a 48-year-old male, had been treated by 11,000 rad of radiotherapy for a squamous cell carcinoma on the left side of tongue. 5 years later, a rapidly enlarging mass was found from the same side of the mouth floor. Microscopic features showed the proliferation of spindle cells with vague storiform pattern. Immunohistochemicaliy the tumor was positively reacted with the antibodies for vimentin, alpha-1-antichymotrypsin, but cytokeratin was not demonstrated. This tumor was thought to be malignant fibrous histiocytoma.