백서에서 술전 스테로이드 투여에 따른 술후 조직 부종의 변화

Effect of presurgical administration of dexamethasone on experimental postsurgical edema in rats

The purpose of this study was to determine the most appropriate time to administer dexamethasone presurgically for reduction of experimental postsurgical edema in rats. Total 105 rats, Spargue Dawley Strain, each weighing about 200-300g, were used and divided into 5 groups: control group consisting of 25 rats; Experimental group 1, 2, 3, 4 were administered dexamethasone(1.5㎎/㎏) intramuscularly just before, 6, 12, 18 hours before operation. Edema was produced by the surgical procedures on the mandibular angle in rats. The obtained results were as follows; The mean percent of water in normal tissue was 74.5%. In control group, mean percent of water increased to 77.4% at the 24 hours, 77.9% at the 48 hours, 80.0% at the 72 hours, and 78.5% at the 96 hours postoperatively. Among experimental groups(group 1, 2, 3, 4), the most effective control of postsurgical edema was observed in group 3 and maximum effect was appeared on 72 hours postoperatively. Histopathologically control group showed greater distortion of architecture with a moderate inflammatory infiltrate and vascular disruption than experimental groups. Experimental group 3 showed much less inflammatory infiltrates than any other groups at 72 hours after operation. In the present study, surgically produced swelling peaked between 48 and 72 hours after injury and could be greatly suppressed by the preoperative intramuscular administration of dexamethasone.