PMMA (Bone cementⓇ)가 家兎의 顎骨 損像部治癒에 미치는 影響

The effect of PMMA (one cementⓇ) on the healing process of defect in rabbit

The purpose of this experimental study was to observe the tissue tolerance, the rate of new bone formation, and influence in the healing process of bony defect after PMMA insertion in the mandible of rabbits. Eight hybrid white rabbits were selected in experimental animals: Control group in right side and experimental group with PMMA insertion in left side (10㎜ in measured dimeter). Each of the experimental animals was sacrificed on the 1st, 2nd, 4th, 8th weeks postoperatively and mandible was removed. Then the specimens were fixed in the 10% neutral formalin solution for 24 hours and decalcified with nitric acid mixed with formalin (1:9), and then embeded in paraffin, sectioned 6㎛ thickness and stained with hematoxylin eosin statin. The result were as follows: In all experimental periods, there were no any inflammatory and foreign body reaction. The implanted PMMA was encapsulated by delicate fibrous tissue capsule and entrapted by muscle fibers inserting into adjacent bone. The bony defects were replaced by fibromuscular tissue and reconstructed by osteoblastic reaction around the implanted PMMA. The healing process and bone formation were relatively favorable in PMMA implanted groups than in control groups. At 8th weeks, direct bone accumulation around the implanted PMMA separated by only delicate fibrous membrane was noted which resulted in bony union.