신생아의 구순열, 구개열의 발생빈도 및 발생요인에 관한 통계적 연구

The statistical study on the incidence and related factors of cleft lip and palate

In terms of frequency, cleft lip and cleft palate rank high on the list of congenital deformities. Unfortunately, little is known regarding the etiology of these malformation, and there is even disagreement as to their frequency of occurrence and relationship to such elements as heredity and environmental factors. In order to attempt adding the statistical data on the incidence of this malformation and shedding some light on the related factors, we studied 123 cleft babies who were born at the 18 general hospitals, located in Seoul during the past 6 years from 1981 to 1986. The following results were obtained. 1. 123 babies of cleft lip and/or palate born among 149191 deliveries, and clefts birth rate was 1213:1. 2. The cleft lip birth rate was 4813: 1, cleft palate birth rate was 4263: 1, cleft lip and palate birth rate was 2617: 1. 3. In general, males were affected about 1.5 times more than females. In cleft lip, cleft lip and palate, males were affected 3 and 1.5 times respectively than females but in cleft palate, females were affected 2 times than male. 4. Cleft birth rate by incidence of year of birth, month, parity and maternal age, was not statistically significant. 5. The incidence of prenatal history during the first trimester was reported on the 21 babies (17.7%) and disease was 4 case, medication was 21 case. 6. The number of associated anomalies were found on the 19 babies (15.4%). 7. Presenting positive family history of cleft patient was ony 3 case and 2.4% of total numbers. 8. Full term pregnancy was reported as 79.4% and prematurity was 17%, simultaneous prematurity and associated anomalies were reported 7 case, cleft lip and palate was 5 case, cleft palate was 2 case.