염산 테트라싸이크린 용액에 처리한 Gelfoam이 백서악골 손상치유에 미치는 영향에 관한 연구

A STUDY ON THE EFFECT OF TETRACYCLINE HCL. TREATED GELFOAM PREPARATION ON THE HEALING OF EXPERIMENTAL BONE DEFECT OF RATS

This study was undertaken to evaluate the effects of Tetracycline Hcl solution treated on the healing process of rat s mandibular bony defacets. 24 rats, sprague dawley strain, weighing about 400gm, were used, devided into control group (4 rats) and experimental group(20 rats) Six rats were sacrificed every one week serially for four weeks and prepared microscopic slides with Hematoxylin-Eosin stain for pathological examination. The obtained results from this study were as follows. 1. Marked acute and chronic inflammatory cell infiltration was found in first week control group and it showed decreasing thendency in second week control group. Bony defects were filled with young fibroflasts proliferation in first and second week control groups. 2. New bone formation was found in the second week control group and bony defects were filled with osseous tissue in fourth week control group. 3. infiltration of Inflammatory cells, necrotic bone tissue and foreignbody reactin were noted only in first experimental group. 4. New bone formation was noted in second week experimental group and bony defects were replaced with new bone formation complately by fourth week experimental group which was very similar to the control group. 5. Periosteal bone formation was noted in all phases of control and experimental group. 6. In experimental groups, the inflammatory reaction and new bone formation were very similar to control groups, thus it may give advise of using Tetracyclin Hcl treated Gelfoam in routine clinical practice.