Gelfoam이 백서악골 손상치유에 미치는 영향에 관한 연구

A STUDY ON THE EFFECT OF GELFOAM PREPARATION ON THE HEALING OF EXPERIMENTAL BONE DEFECT OF RATS

This study was undertaken to evaluate the effects of Gelfoam preparations on the healing process of rat s mandibular bony defects. 24 rats, sprague dawley strain, weighing about 400gm were used, devided into control group (4 rats) and experimental group (20 rats) Six rats were sacrificed every one week serially for four weeks and prepared microscopic slides with Hematoxylin-Eosin stain for pathological examination. The obtained results from this study were as follows. 1. Acute and chronic inflammatory cell infiltration was remarkable in first week control group and it showed decreasing tendency in second week control group. 2. New bone formation was found in second week control group and bony defect was filled with osseous tissue devoiding of lamella structure. 3. Inflammatory cell infiltration was obvious up to second week experimental group, foreign body reaction and necrotic bone were also observed. 4. New bone formation was noted in third week expeimental group and it showed very similar findings with control group in fourth experimental group. 5. There was no definit distinction both in control and experimental group as to periosteal bone formation. 6. There were persistant inflammatory reaction and delayed new bone formation in experimental groups compared with control groups by fourth weeks. Healing process was essentially the same in all groups.