당뇨병백서 구강점막의 창상치유에 관한 실험적 연구

THE EFFECT OF DIABETES MELLITUS ON THE WOUND HEALING OF RAT PALATAL MUCOSA

To obsered the effect, of diabetes mellitus on the wound healing of rat palatal mousa, the auther induced diabetes mel1itus by the use of streptozotocin to the rats and made incisional wound on the palatal mucosa. The results were as follow. 1. At the first day of experiment, trio histologic findings of wound healing were quite similar in both experimental and control group. But at the 3rd day of experiment, the inflammation and tissue destruction were extended widely through the surrounding structures of the wound in diabetic rats in compare with the control group. 2. The healing of wound was markedly delayed in diabetic rats, and it was completed at the 6th week in diabetic rats, whereas the wound healing was completed at the 2nd week in control group. 3. In control group the epithelization begun at the first day of experiment and completed at 1st week with epithelial spur formation. Although the epithelium covered the wound surface completely at the 1st week of experiment in diabetic rats, it was thin and flat without rate peg formation until the 4th week. 4. In diabetes group, the granulation tissue exist uP to the 4th week and replaced by scar tissue at the 6th week. And the collagen deposition begun at the 1st week of experiment. In control group collagen deposition begun at the 3rd day and granulation tissue was replaced by normal submucosal connective tissue at the 2nd week.