Steroid투여가 술후 부종에 미치는 영향에 관한 실험적 연구

AN EXPERIMENTAL STUDY ON THE EFFECT OF STEROID ON POSTSURGICAL EDEMA IN RATS

Varying degrees of edema follows after many oral surgical procedures, although numerous methods for minimizing edema habe been advocated. No technique has gained complete acceptance. A major problem has been the inability to document the efficacy of suggested treatments convincingly. This study was undertaken to quantitate edema by measuring differences in percentage of water content between operated and unoperated tissues and to evaluate the effect of steroid to reduce the edema. 35 rats, Sprague Dawley strain, weighing about 300gm, were used, divided into control group(5 rats) and 3 experimental groups consisting of ten animals respectively. Group Ⅰ received no steroids, Group Ⅱ low-dose steroid (0.3 mg dexamethasone/kg) and Group Ⅲ high-dose steroid(1.0 mg dexamethasone/kg) intramuscularly immediately prior to surgery. The obtained results from this study were as follows. 1. At 24 hours after surgery, percentages of water content were lowered in steroid-treated groups than nonsteroid-treated group; however, the higher dose of steroid was associated with a relatively greater reduction of postoperative edema than was the lower dose. 2. At 48 hours after surgery, percentages of water content were lowered slightly in steroid-treated groups than nonsteroid-treated group; however, the differences was not significant, statistically.(p>0.05) 3. In histopathological findings, less of inflammatory cell infiltration, muscle damage and vessel dilatation as antiinflammatory effects showed in steroid-treated groups in comparison with nonsteroid-treated group. Of the two steroid-treated groups, group treated with higher dose of steroid showed more prominent anti-inflammatory effects.