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EXPERIMENTAL STUDY FOR THE INITIATION OF IRRADISATION EFFECTS ON THE TOOTH EXTRACTION WOUNDS IN RATS

Removing teeth prior to irradiation therapy from patients with head and neck milignancy is a subject of controversy. One unsettled point concerns the interval between the time of extractions and initiation of radiotherapy. Several authors including Wildermuth have discussed the dangers the dangers that they think are associated with irradiation of extraction sockets, while others have stated specifically and without qualification that all teeth directly in the beam should be extracted prior to such therapy. The author studied, evaluated the postirradiation response of 60 rats who had teeth removed and who received irradiation of 1500rads single dose using 8 MeV Electron Beam(Lineac Accelerator Unit) directly to the extraction wounds every once in a week for the period of five weeks, thus, the intraoral sequelae were studied in relation to the time period between extractions and the initiation of radiotherapy. Obtained results of this experimental study were as follows. 1. The healing processes of teeth extractions wounds as well as osteoblastic activities were delayed remarkably in experimental group than that of control group. 2. The signs of early healing of extraction wounds were observed in control groups in first and second weeks postoperatively while the signs were delayed till third, fourth and fifth weeks in experimental groups. 3. Osteroradionecrotic changes were observed till in the third week postoperative groups of experimental group. 4. The results of this experimental study indicate that minimum time relapse between the initiation of irradition therapy and the tooth extraction was three weeks to prevent side effects and the first postoperative week was the most dangerous period for the irradiation therapy.