食餌性 蛋白質含量에 따른 흰쥐에 四鹽化炭素 投與가 Guanase 活性變動에 미치는 영향

Effect of Carbon Tetrachloride on the Changes of Guanase Activity in-Rats Fed Low or High Proteins Diet

The effect of hepatic injury produced by CCL, was studied on rats receiving a low protein-high carbohydrate (7% casein), standard protein (20% casein) and a high protein diet (30% casein). The rats fed low protein diet are resistant to CCl₄ in its effects on the liver as judged by histology, serum enzymes(guanase, ALT) and the content of hepatic protein. On the other hand, the pretreatment of hydrocortisone before injection of CCl₄ to the rats fed a standard diet, slightly decreased both serum ALT and guanase activities. In the pretreatment of actinomycin D, the liver and serum guanase activities were significantly decreased. It indicates that the cause of increasing serum guanase is based on the alteration of membrane permeability and the result of accelerated enzyme synthesis in liver cells of CCl₄ intoxicated rats.