抗癌劑投與가 口腔粘膜에 미치는 影響에 關한 實驗的 硏究

THE EXPERIMENT AL STUDY ON THE EFFECTS OF CYCLOPHOSPHAMIDE TO THE SOFT TISSUES OF ORAL CAVITY

The purpose of this study was to evaluate the effects of Cyclophosphamide to the soft tissues of the rabbit oral cavity, especially such as palatal, buccal and tongue mucous membranes, and palatal tonsil. Nineteen yonng mile adult rabbits were used and divided into two groups like control group were injected 1 cc. normal saline solution as placebo, and experimental group were injected 30mg. Cyclophosphamide per 500Gm. body weight. Thereafter body weight and temperature were measured on 1st, 3rd, 5th, 7th, 10th, and 14th day after injections of placebo and Cyclophosphamide, and sacrificed in order to make preparations and observed histopathalogical findings. The results were drawn as follows: 1. Slightly keratinization and atrophy of oral mucosa were followed by the injection of Cyclophosphamide. 2. The administration of Cyclophosphamide caused tongue papilla atrophies such as circumvallate, fungiform and filiform papillae. 3. The lymphocytic infiltration was more prominent in the control group than that in experimental group injected Cyclophosphamide. 4. Decreasing body weight and dropping body temperature were followed in experimental group injected Cyclophosphamide.