X-線 照射에 의한 마우스 染色體의 SCE 頻度와 染色體異常

The Sister Chromatid Exchange Frequencies and Chromosome Aberrations in Mouse Lymphocyte by X-Ray Irradiation

This study was carried out to investigate the effects on sister chromatid exchanges (SCEs) and chromosome aberrations in PHA or LPS stimulated mouse spleen and bone marrow lymphocytes after an acute whole body irradiation. Frequencies of sister chromatid exchanges were significantly increased with the increased dose(from zero to 400rad) but there was no differences between ß-cell and T-cell. ßy times, the maximum induced SCE levels was observed at 12 hours after irradiation and then returned to base level at one day in 100rad group and three day in 400rad group. There was a significant difference in chromosome aberration with increasing exposure. X-ray irradiated chromosome aberration was long lived relative to SCE. This results show that counting the incidence of SCE may not provide a sensitive system for detecting X-ray exposure.