흰쥐에 四塩化炭素投與時 小腸 Xanthine Oxidase 活性 變動

An Effect of Carbon Tetrachloride Treatment on the Xanthine Oxidase Activity of Small Intestine in Rats

An effect of carbon tetrachloride (CCl₄) was studied on the xanthine oxidase(XOD) activity of small intestine in male rats. Concomitantly a cause of increasing small intestine XOD was focused on an effect of actinomycin D and the kinetics of partial purified XOD from small intestine in CCl₄ intoxicated rats. An injection of CCl₄ to the rats showed an increase of small intestine XOD. In the pretreatment of actinomycin D before injection of CCl₄ to the rats, the XOD activities of small intestine were significantly decreased. In the partial purified enzyme preparation, the small intestine XOD in CCl₄ intoxicated rats showed the more increased Km and Vmax value with xanthine as substrate than that of control group.