Captafol (1 H -isoindole- 1.3 (2H)-dione. 3a, 4, 7, 7 a-tetrahydro-2- 1.1. 2.2-tetrachloroethylthio), is widely used as broad spectrum fungicide in agriculture and industrial application N-sulfenylphthalimide fungicides are relatively low toxic to human and animal by oraJ. administration. However it was reported that the fungicides have carcinogenic and mutagenic potentials‘ in subacute and chronic toxicity experiments. As mentioned the above, there are many experimenta! reports on the toxicity of captan and folpet , the toxicological researches on captafol are few , therefore in this experiment we examined the subacute toxicity of captafol which is widely used as fungicide in biochemical parameters in serum‘ The experimental resu!ts were summerized as follows : 1) 1n captafol administered group, the body weight was significantly decreased but the biochemical parameters such as AST, AL T, LDH, BUN, TG in serum were remarkably e!evated in comparison to that of control group 2) Captafol plus ethanol administered group‘ serum AST, AL T, BUN were elevated in comparisont that of captafol treated group.
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