微量金屬 暴露에 있어 生體試料의 特性(第l 報)

Studies on the Characteristics of Biological Samples under the Exposure of Trace Metals (Report 1)

These studies were carried out to find out some characteristic responses of biological samples under the exposure of trace metals. In anirnal experiment. six rats per week were killed for 6 weeks under Cd exposures and the concentrations of Cd, Cu and Zi1 in their organs and blood were deterrnined by flame atornic absorption spectrophotometry. The results were sumrnarized as follows : 1. In animal experiments, the concentrations of Cd in the liver and kidney of Cd exposure groups were increased, however, the values of hernatocrit and hemoglobin in blood were decreased remarkably. The body weight of the Cd exposure groups showed lower trend than that of control group. The concentrations of Cd in heart, lung and testes were increased slowly during the first 2 weeks. The concentrations of Cd in their organs decreased while the rapid increase of the concentration of Cd in the liver and kidney was observed. While rapid increase of the concentration of Cd in the liver and kidney was observed, the concentrations of Cd in the organs were decreased afterward and increased again while the low increase of the concentration of Cd in the liver and kìdney was observed. The concentrations Cu and Zn were increased rernarkably in all the organs for first 2 and 3 weeks. In the exposure groups of Cd+Cu and Cd+Zn, the liver and kidney didn’t show lower concentration of Cd than that of Cd group.