The role of nuclear factor I-C in tooth and bone development
- 대한구강악안면외과학회
- 대한구강악안면외과학회지
- 대한구강악안면외과학회지 제43권 제2호
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2017.0463 - 69 (7 pages)
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Nuclear factor I-C (NFI-C) plays a pivotal role in various cellular processes such as odontoblast and osteoblast differentiation. Nfic-deficient mice showed abnormal tooth and bone formation. The transplantation of Nfic-expressing mouse bone marrow stromal cells rescued the impaired bone formation in Nfic-/- mice. Studies suggest that NFI-C regulate osteogenesis and dentinogenesis in concert with several factors including transforming growth factor-β1, Krüppel-like factor 4, and β-catenin. This review will focus on the function of NFI-C during tooth and bone formation and on the relevant pathways that involve NFI-C.
Abstract
I. Introduction
II. General Description of the NFI Family of Transcription Factors
III. Function of NFIC in Dentinogenesis
IV. Function of NFIC in Osteogenesis
V. Other Prominent Factors in Odontogenesis and Osteogenesis
VI. Conclusion
References
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