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The role of nuclear factor I-C in tooth and bone development

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Nuclear factor I-C (NFI-C) plays a pivotal role in various cellular processes such as odontoblast and osteoblast differentiation. Nfic-deficient mice showed abnormal tooth and bone formation. The transplantation of Nfic-expressing mouse bone marrow stromal cells rescued the impaired bone formation in Nfic-/- mice. Studies suggest that NFI-C regulate osteogenesis and dentinogenesis in concert with several factors including transforming growth factor-β1, Krüppel-like factor 4, and β-catenin. This review will focus on the function of NFI-C during tooth and bone formation and on the relevant pathways that involve NFI-C.

Abstract

I. Introduction

II. General Description of the NFI Family of Transcription Factors

III. Function of NFIC in Dentinogenesis

IV. Function of NFIC in Osteogenesis

V. Other Prominent Factors in Odontogenesis and Osteogenesis

VI. Conclusion

References

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