ω-3 고도불포화지방산이 흰쥐의 혈청 지질과 cytokines 에 미치는 영향

The effect of ω-3 polyunsaturated fatty acids on serumlipid and cytokines of rats

This study was designed to examine the effect of ω-3 fatty acid, linlenic acid. EPA, DHA on serum lipid and cytokines of male rats(Sprague-Dawley). Animals of 3 groups were administrated perilla oil, salmoon oil, and tuna oil of 0.4 ㎖/day for 8 weeks respectively. These oils were used for a source of linolenic acid, EPA and DHA. ω-3 polyunsaturated fatty acid decrease significantly body weight, serum PGE₂ content and serum cytokines content of the rat, and increases internal organs weight, specially liver weight and serum HDL-cholesterol level of the rat. In the results, authors propose to use perilla oil for source of effective ω-3 poly-unsaturated fatty acid(linolenic acid) to Prevent cardiovascular and immune diseases.