게껍질로부터 CM-Chitin의 합성

Synthesis of CM-Chitin from Crab Shells

Chitin was isolated from crab shells by modified Hackman s method, which was treated again with aqueous sodium hydroxide solution to give alkali chitin(sodium alkoxide of chitin). And after, the alkali chitin is allowed to react with monochloroacetic acid to synthesize 6-O-(carboxymethyl) chitin [CM-Chitin] under diminished pressure. In order to synthesize high performance CM-Chitin as hygroscopic agent, it was measured that the yield and degree of subsititution of each CM-Chitin according to molar ratio(monochloroacetic acid equivalent mol/N-acetyl-D-glucosamine residue) and their moisture-absorption and moisture-release properties were measured and compared with those of hyaluronic acid. The moisture-absorption and moisture-release properties of CM-Chitin. especially 0.8 in degree of substitution, were found quite similar to those of hyaluronic acid. The preliminary results show that CM-Chitin might be used as hygroscopic agent instead of hyaluronic acid in field of cosmetics.