학술저널
새로운 Aminoisoquinolinylamide 유도체의 합성 및 흑색종 저해 효능
Synthesis and Melanoma Inhibitory Activity of New Aminoisoquinolinylamide Derivatives
- 한국응용과학기술학회 (구.한국유화학회)
- 한국응용과학기술학회지
- 한국유화학회지 제26권 제2호
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2008.06161 - 170 (10 pages)
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In this work, a novel series of aminoisoquinolinylamide derivatives 1a-c and 2a-f were synthesized via several reaction steps, starting from 2-methyl-4-nitrobenzonitrile (3) and 1-chloro-5-nitroquinoline (8). And their antiproliferative activities were screened against A375 human melanoma cell line compared to Sorafenib as a reference compound. Among them, compound 1b and 1c exhibited meaningful inhibitory activities. These results demonstrated that aminoisoquinolinylamide scaffold possesses the possibility as the treatment for melanoma.
Abstract
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3. 결과 및 고찰
4. 결론
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