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새로운 Aminopyrimidinylmethanone 유도체의 합성

Synthesis of New Aminopyrimidinylmethanone Derivatives

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In this work, the synthetic approaches for a series of aminopyrimiclinylmethanone derivatives 1a-i, which versatile biological activities such as antibacterial and anticancer activities are expected from a structural point of view, were described. Nicotinic acid was converted to (2-methylsulfonylpyrimidin-4-yl) (pyridin-3-yl)methanone, a key intermediate, which was reacted with nucleophiles to yield the desired aminopyrimidinylmethanone derivatives 1a-i bearing various substituents.

Abstract

1. 서론

2. 실험

3. 결과 및 고찰

4. 결론

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