학술저널
Licochalcone E 유도체들이 LPS에 의해 유도된 염증조절 분자들의 생성에 미치는 영향
Effects of Licochalcone E Derivatives on the Production of Inflammatory Mediators Induced by LPS
- 대한약학회
- 약학회지
- 제61권 제3호(2017년)
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2017.06171 - 177 (7 pages)
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DOI : 10.17480/psk.2017.61.3.171
- 44
Licochalcone E is a retrochalcone isolated from the roots of Glycyrrhiza inflate. We previously reported that licochalcone E inhibited IL-12p40 production and attenuated chronic allergic contact dermatitis (ACD). Among the derivatives of licochalcone E, compound #74 ((E)-3-(5-Bromo-4-hydroxy-2-methoxyphenyl)-1-(4-ethoxyphenyl)prop-2-en-1-one) inhibited the production of IL-12p40, TNF-α, and IL-6, and NF-κB signaling pathway from LPS stimulated RAW264.7 macrophages. The effect of compound #74 (0.5, 1, and 5%) on ACD model was very weak.
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