Pre-Clinical Study of Risperidone

A pre-clinical study can explore the pharmacology, mechanism of actions and toxicology of candidate substances for new therapeutic drugs, and the additional biological mechanisms of drugs currently prescribed in clinical practice. An in vitro study can be utilized for investigating the mechanism of actions at the molecular level, drug resistance, factors determining the drug responses, intracellular pharmacodynamics and molecular pharmacology, and an in vivo study can be applied for evaluating the therapeutic effects and toxicology on living animals, and for allowing to determine the initial clinical doses. Last ten years, only a few pre-clinical studies of risperidone, dealt with biochemical studies related with dopamine neurotransmission, Fos-immunoreactivity, animal models of obsessive-compulsive disorder and neuroprotection in dementia, has been reported in Korea. In this manuscript, the issues related to the pre-clinical studies of risperidone conducted in Korea were summarized with journal reviews obtained through PubMed.