Nonylphenol에 장기간 노출된 붕어, Carassius auratus 기관계의 조직병리학적 변화

Histopathological changes in the organs of the crucian carp, Carassius auratus (Teleostei: Cyprinidae) long-term exposed to nonylphenol

Toxicity of nonylphenol one of EDCs was studied with focus on crucian carp, Carassius auratus. Fishes were cultured under the control and the nonylphenol exposure conditions for 32 weeks. Experimental group were composed of total of 4 groups that 1 control condition and 3 nonylphenol exposure conditions (18.28, 36.76 and 82.70 ㎍ NP L-1). The skin exposed to nonlyphenol showed degeneration and atrophy of mucous cells, atrophy and necrosis of epidermal layer and hypertrophy of club cells. In the case of gill, it was showed hyperplasia of the filament epithelia, appearance of melano macrophage center and lifting of the lamella epithelial layer. Moreover, in 82.70 ㎍ NP L-1 group, gills showed necrosis of the filament and lamella. Liver in fish exposed to nonylphenol were characterized by cloudy cytoplasm, atrophy of nucleus and necrosis of hepatocytes. The kidney of fish exposed to nonylphenol was observed PAS positive materials in the lumen of the several renal tubule, appearance of eosinophilic granular cells and necrosis of glomerulus and renal tubule. Results of this study suggest that nonlyphenol induce severe histopathological changes in the organs of Carassius auratus.