한국인 남성 알코올 의존 환자에서 제2알데히드 탈수소 효소 유전자형과 도파민 D2 수용체 A1 대립유전자의 빈도에 관한 비교 연구

The Comparison of Frequencies of Aldehyde Dehydrogenase 2(ALDH2) Genotypes and A1 Allele of Dopamine D2 Receptor(DRD2) Gene in Korean Male Alcohol Dependence Patients

The purpose of this study is to evaluate the association polymorphic patterns of DRD2 and ALDH2 gene with alcohol dependence. The patient group consisted of 47 male patients with alcohol dependence and the control group consisted of 20 healthy male volunteers without alcohol dependence. Polymorphic patterns of ALDH2 gene and DRD2 gene were determined by PCR method. And then we compared allele frequencies of two loci between patient and control groups. The results were as follows：1) The frequencies of ALDH2*1/1 in patient group were significantly higher than those in the healthy controls. The frequencies of mutant ALDH2 (ALDH2* 1/2 and ALDH2*2/2) were significantly lower in patient group than those in healthy controls. 2) There was no significant difference in A1A1 A1A2 A2A2 genotype frequencies in DRD2 gene between patient group and healthy controls. 3) In patient group with A1 allele, frequencies of ALDH2*1/1, ALDH2*1/2, ALDH2*2/2 were 61.7%, 3%, 0%, respectively. In patient group without A1 allele, frequencies of ALDH genotypes were 29%, 2%, 0%, respectively. In conclusion, mutant ALDH2 genotype seems to have influence on the occurrence of alcohol dependence. The interaction of DRD2 A1 alleles and ALDH2 alleles should be studied to find some effect on pathogenesis of alcohol dependence.