정상 성인에서 ALDH2 유전형에 따른 알코올 민감성, 음주행태 및 알코올 효과에 대한 기대의 비교

Comparisons of Alcohol Sensitivity, Alcohol Habits and Alcohol Expectancy according to ALDH2 Genotype in Normal Adults

To investigate the interrelations of ALDH2 genotype (biological factor) and alcohol expectancy (psychosocial factor) as the predictors of alcohol use and alcohol-related problems, we compared the alcohol sensitivity, alcohol habits and alcohol expectancy in normal adults with ALDH2 variations. A total of 20 healthy male subjects (the half with ALDH2*1/*1, the other with ALDH2*1/*2) was selected through screening tests and genotyping by amplification created restriction site. The questionnaires for alcohol sensitivity, drinking history and habits, and the modified version of Alcohol Expectancy Questionnaire (AEQ) were administered to the subjects. Data were compared between two groups of ALDH2 genotype. ALDH2*1/*2 subjects reported more negative physiological responses than ALDH2*1/*1 subjects. ALDH2*1/*1 subjects had more frequent histories of alcohol-induced blackouts and consumed more alcohol in terms of frequency and quantity than ALDH2 *1/*2 subjects. ALDH2*1/*1 group showed significantly high scores on negative expectancy, socializing expectancy and tension reduction expectancy scales among 5 subsets of AEQ. This study suggests that the ALDH2 genotype not only clearly affect the alcohol-induced biological responses, but also have the effects on psychosocial dimensions that are related with alcohol use and abuse.