한국 성인 여성의 혈중 알코올 농도와 알코올의 약동학적 특징 및 영향 요인

The Pharmacokinetics of Alcohol in Healthy Korean Female Adults

Background and Objectives ： The aim of this study was to evaluate alcohol pharmacokinetics, such as blood alcohol concentration and alcohol elimination rate, and to identify the cor-relations between various alcohol metabolism factors in healthy Korean female adults. Materials and Methods ： Ninety-one subjects were randomly divided into two groups. One group was provided as much as 0.35 mg/mL/kg of alcohol and the other as much as 0.70 mg/mL/kg, and blood alcohol concentration was measured 15, 30, 45, 60, 90, 120, 180, and 240 min af-ter the women finished drinking. Results ： The subjects’ mean alcohol elimination rate (β) was -0.002379 mg/100 mL·h, and there was no statistically significant difference in elimination rate between the two groups. The mean time to reach maxi-mum blood alcohol concentration was 45 minutes, alcohol ab-sorption rate was 0.1123±0.1799 g/L/min, and the area under the concentration curve was 109.15±62.95. Among the factors that correlated with alcohol metabolism, alcohol absorption rate and follicle-stimulating hormone were statistically significant, but age, body mass index, and body fat percentage were not significantly correlated with alcohol metabolism. Conclusion : These results suggest that the β values for healthy Korean females can differ from the cut-offs that are currently used in Korea, which suggests that the legal limit for driving under intoxication should be adjusted.