다이셀레닐네이션을 이용한 알킬설포닐기가 치환된 새로운 다이피리다지닐 다이셀레나이드의 형성반응
Formation of Novel Alkylsulfonyl Group Substituted Dipyridazinyl Diselenides by Diselenylation
- 대한약학회
- 약학회지
- 제61권 제4호(2017년)
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2017.08222 - 226 (5 pages)
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DOI : 10.17480/psk.2017.61.4.222
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A new series of bis (pyridazinyl) diselenides was synthesized by diselenylation from pyridazinyl chloride for search of antiproliferative agents. The process involves the alkylthiolation, oxidation (sulfonylation and sulfinylation) and diselenylation from 3,6-dichloropyridazine. The alkylsulfonyl (or sulfinyl) pyridazinyl chloride (3c, 4a~4f) could be con-verted to target diorganodiselenides 5c, and 6a~6f with selenium, hydrazine hydrate under atmospheric pressure in the presence of sodium hydroxide. The structures of the synthetic compounds were characterized using 1 H and 13 C NMR spec-troscopy.
실험방법 (Experimental Methods)
실험결과 및 고찰 (Results and Discussion)
결 론 (Conclusion)
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