도파민 수용체 제 2 형 Exon 8 유전자 다형성과 알코올 의존의 임상 양상

DRD2 Exon 8 Polymorphism and Phenotype of Alcohol Dependence in Koreans

Objectives ： Various single nucleotide polymorphisms (SNPs) of dopamine D2 receptor (DRD2) genes have been reported to be involved in the susceptibility to alcohol dependence. We investigated the association of exon 8 (E8) SNP in the DRD2 gene with alcohol dependence in Korean subjects and examined their associations with severities of depression, craving, and alcohol-withdrawal symptoms. Methods ： The DRD2 E8 A/G polymorphisms were genotyped in a case-control sample consisting of 245 alcohol-dependent (AD) patients and 130 healthy controls (HC). Severities of de-pression, craving, and alcohol-withdrawal symptoms were examined with BDI, PACS, and CIWA-Ar in AD patients. Results ： The genotype or allele frequencies of DRD2 E8 A/G had no significant differences between AD and HC groups (χ 2 = 2.659, p=0.265; χ 2 =2.694, p=0.107). AD with A/A genotype and A allele in E8 had significantly higher BDI scores (F=3.705, p=0.029; t=2.073, p=0.040), although there were no significant differences in PACS and CIWA-Ar scores among genotypes or alleles of E8 A/G. Conclusion ： The present study suggests the possibility that DRD2 E8 polymorphisms have an impact on the AD phenotype, such as an increased depressiveness in Korean patients with alcohol dependence.