알코올 의존 환자 제독치료에서 벤조다이아제핀의 Fixed-Schedule doses Therapy와 Symptom-Triggered doses Therapy

Fixed-Schedule versus Symptom-Triggered doses of Benzodiazepine Therapy in Detoxification for Alcohol Withdrawal

Objectives：The aim of this study is to investigate the effect and safety of a fixed-schedule therapy and a symptom-triggered therapy of benzodoazepine for alcohol withdrawal. Methods： Subjectives were 31 alcohol dependence patients and randomized to either the fixed-schedule therapy group or the symptomtriggered therapy group using by URN randomization program. URN randomization’s variables were a history of delirium tremens, CIWA-Ar score and a history of excessive alcohol drinking. Total amount of lorazepam administered and duration of medication treatment were measured. Results：The mean lorazepam dose administered in the symptom-triggered therapy group was 8.47 mg compared with 12.3 mg in the fixed-schedule therapy group (p<.05). The mean duration of lorazepam treatment was 69.3 hours in the symptom-triggered therapy group compared with 95.2 hours in the fixed-schedule therapy group (p<.05). Conclusion：Symptom-triggered therapy decreased both the amount of benzodiazepine used and treatment duration, and was as efficacious as fixed-schedule therapy for alcohol withdrawal.