안지오텐신 전환 효소 유전자 다형성과 알코올 의존

Angiotensin-Converting Enzyme Gene Polymorphism and Alcohol Dependence

Objective：There is increasing evidence that Renin-Angiotensin System is involved in the pathophysiology of alcoholics. This study was performed to examine the relationship between Renin-Angiotensin System and alcoholics by analyzing polymorphism of Angiotensin converting enzyme (ACE), an compartment of Renin-Angiotensin System. Methods：We examined the frequency of a polymorphism of the ACE gene (located on chromosome 17q23) in groups of patients with alcohol dependence (n=99) compared to healthy control subjects (n=177). ACE genotype was determined by size-analysis of polymerase chain reaction products. Results：No difference was found between the alcohol dependent patients and the controls in genotype and allele frequencies of the ACE I/D polymorphism. Significant difference of FTND score was found among ACE genotype groups in alcohol dependent patients (F=3.657, df=2,96, p= 0.029). Significant difference of impulsiveness of non planning and impulsiveness of motor was found among ACE genotype groups in alcohol dependent patients who started first drinking at 19 years or more (IONP F=6.921, df=2,60, p=0.002；IOM F=3.913, df=2,60, p=0.025). Conclusion：These results do not support an association between polymorphism of ACE gene and alcohol dependence. It is suggested that I/D polymorphism in the ACE gene could be associated with nicotine dependence severity in alcohol dependent patients and with alcohol dependence patients who started first drinking at 19 years or more.impulsiveness in