니코틴 의존자에서 인지행동 단독치료와 Naltrexone 추가치료 간의 흡연행동 비교

Comparision of Smoking Behavior Change between Naltrexone Add-On Therapy and Cognitive Behavioral Therapy Alone in Nicotine Dependence

Objectives：The present study was performed to evaluate the effectiveness of naltrexone combined CBT(cognitive behavior therapy). Method：This study design was double blind placebo controlled method. Naltrexone(n=13) and placebo(n=12) were added to CBT for 2 weeks in 25 subjects. Administered Naltrexone dosage was 23.4 mg/day in 1st week and 37.1 mg/day in 2nd week. Multimodal CBT technique was conducted for three times once every week. Total cigarette consumption amounts per a week, Brief Questionnaire for Smoking Urge (B-QSU), and expiratory CO levels, Fagerstrom Tolerance Questionnaire (FTQ) were checked at baseline and 4 weeks later. Results： 1) There were no differences between naltrexone add-on CBT group and CBT alone group in nicotine withdrawal symptoms and drug side effects containing GOT/GPT levels. 2) In Naltrexone add-on CBT group, total cigarette consumptions (p=0.021), the expiratory CO levels (p=0.039), B-QSU score (p=0.036), and FIQ scores (p=0.028) were significantly lower than CBT alone group. 3) Subjective reports about the smoking reduction are greater in naltrexone add-on CBT group than CBT alone (53.0% vs. 16.7%). Conclusions： Naltrexone and CBT combined therapy could be a effective and safe treatment in nicotine dependence.