입원한 알코올 의존 환자의 임상적 특성 및 Aldehyde Dehydrogenase II와 Arylsulfatase A 유전자 다형성

Clinical Characteristics and Gene Polymorphisms of Aldehyde Dehydrogenase II and Arylsulfatase A in Hospitalized Patients with Alcohol Dependence

Aldehyde dehydrogenase II (ALDH2) and arylsulfatase A (ASA) gene polymorphisms were explored for the association of alcohol dependence and/or its clinical characteristics. Polymerase chain reaction and restriction fragment length polymorphism were used to determine the genotypic and allelic frequencies of 128 male hospitalized alcoholic patients who met DSM-IV criteria for alcohol dependence and 128 agematched healthy male control subjects. The ALDH2 genotypic frequencies in alcoholic patients were 0.992 (NN), 0.008 (ND), and 0.000 (DD), which were significantly different from those of control subjects (0.484, 0.430, and 0.086, respectively). The ASA genotypic frequencies at the pseudodeficient Nglycosylation and polyadenylation sites showed grossly no differences between alcoholic patients and control subjects. There was no association between genotypic distributions of ALDH2 and ASA and clinical characteristics of alcohol dependence. These results suggested that the D allele of ALDH2 gene has a protective role against alcohol dependence. The further extensive researches for the relationship between alcohol dependence and the pseudodeficient ASA gene polymorphisms are required.