알코올 의존 환자에서 12개월간 Naltrexone과 Acamprosate의 투약 순응도 비교

Comparisons of Naltrexone and Acamprosate’s Medication Compliance for 12 Months in Patients with Alcohol Dependence

Objectives ： Within the field of study concerning alcoholism, there is mounting evidence supporting an important relation-ship between medication compliance and drinking outcomes. Research has suggested that naltrexone’s effectiveness can be greatly influenced by the compliance of participants in clinical trials. The effect of medication compliance on the efficacy of acamprosate is less well studied. Thus, much more data is needed to be known about the differential impact of medication com-pliance on alcohol patients involved with different medications. Methods ： The subjects were consecutively admitted alcoholic patients who were diagnosed with alcohol dependence ac-cording to DSM-IV diagnostic criteria from January, 1998 to December, 2007 in Incheon christian hospital. Medication compliance was defined as whether they had prescribed 80% or more of the maximum number of pills during treatment. The subjects were assessed at 3 month intervals over a 1-year OPD follow-up period by chart review. Results ： Naltrexone group showed better medication compliance than no-medication group at 3, 6 and 12 month and acamprosate group at 3, 6 month. Acamprosate group had better medication compliance and OPD follow up rate than no-medication group at only 12 month. Conclusion : Acamprosate and no-medication group were found to be less effective than naltrexone in helping patients in terms of medication compliance that needs further study.