Correlation between retromer and neurological diseases including Alzheimer

Retromer is an important endosomal trafficking protein assembly that takes part in transporting the membrane cargo. Endosomal trafficking involves sorting of proteins from the endosome and transporting them through different pathways in the cell. The three major pathways of endosomal trafficking are recycling, retrograde, and degradation pathways; retromers are involved in the first two types of pathways. Since 2005, many researches have studied the correlation between retromer and different neurodegenerative diseases. Since the first study on Alzheimer s, numerous studies on other neurodegenerative diseases, including Parkinson’s disease and Neuronal Ceroid Lipofuscinosis, revealed that dysfunction of the retromer contributes to these afflictions. It is therefore important to understand the molecular mechanism behind the process. Recent studies have shown the potential of retromer as a drug target. Therapeutic agents, such as retromer chaperone, have been found to improve the function of retromer without affecting other pathways.