새로운 메틸 3,4-디알킬카보닐옥시-5-메톡시벤조에이트 유도체의 합성 및 항산화와 세포증식억제 작용

Antioxidant, Antiproliferative Activity and Synthesis of Novel Methyl 3,4- Dialkylcarbonyloxy-5-methoxybenzoate Derivatives

The antiproliferative and antioxidative properties of novel polyphenolic acid derivatives, structurally related with the natural model gallic acids, have been tested in cancer cell lines (MCF-7, Hep3B, RKO) and lipid peroxidation. A new series of methyl 3,4-dialkylcarbonyloxy-5-methoxybenzoate 4a~4e was synthesized by acylation from O-methyl gallicin 3 for search of bioactive compounds. The structures of the synthetic compounds were characterized using ¹H, ¹³C NMR and HRMS spectroscopy. Two target compounds (4c, 4d) showed higher potency than propyl gallicin or drumstick-tree (Moringa oleifera Lam.) extracts for inhibiting the growth of cancer cell lines (MCF-7, Hep3B, RKO). The antioxidative properties of 4b among synthetic compounds was similar to the antioxidant propyl gallate and α-tocopherol.