B16 흑색종세포에서 아라키돈산 유발 활성산소종의 멜라닌 합성 촉진 효과

Effects of Reactive Oxygen Species Induced by Arachidonic Acid on the Stimulation of Melanin Synthesis in B16 Melanoma Cells

Arachidonic acid (AA) increased production of reactive oxygen species (ROS) in B16 melanoma cells. The AA-induced ROS production and melanogenesis were significantly blocked by treatment with DPI and DIOA, specific inhibitors of NADPH oxidase and K⁺₋Cl⁻₋cotransport (KCC), respectively. These results suggest that ROS production by the KCC-linked activation of the NADPH oxidase may play a role in the AA-induced melanogenesis.

Abstract

실험 방법(Experimental methods)

실험 결과 및 고찰(Results and discussion)

결론(Conclusion)

감사의 말씀(Acknowledgement)

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