인삼 추출물의 치매유도 동물모델에 대한 기억력 개선효과

Effect of Ginseng Extract on Memory Improvement in the Amnesic Mice

This study investigated the effect of black ginseng on the learning and memory impairment induced by scopolamine (SCOP, 2 mg/kg) compared with white, red, and black ginseng (WGE, RGE, BGE, 200 mg/kg). Tacrine (10 mg/kg) was used as a positive control. Ginseng-treated groups significantly reversed scopolamine-induced memory impairment in passive avoidance test and also reduced escape latency in training trials of the Morris water maze test. The increased AChE activity induced by SCOP was significantly inhibited by oral treatment of WGE and RGE extract (p<0.001). SCOP administration did not change ChAT activity, but RGE and BGE significantly increased ChAT activity (p<0.05). These results suggest that black ginseng showed the potential cognitive-enhancing activity by regulating cholinergic marker protein.