蜂毒療法의 筋骨格界疾患 治療機轉에 대한 文獻的 考察

The Study of Literature Riview on Mechanism of Bee Venom Therapy for Musculo-skeletal Disorder

Objectives : There have been many studies of the effect of Bee Venom therapy about arthritis, but no one study was reported about its whole functional mechanism to musculo-skeletal system. This study was designed to investigate the effect, indication, and side effect of Bee Venom therapy on musculo-skeletal disease by literature riview of articles. Results : The effects of Bee Venom therapy to musculo-skeletal system are divided to Anti-inflammatory effect and Anti-nociceptive effect. Anti-inflammatory effect is achieved through competitive chemotaxis, immuno-regulation, increasing of cortisol secretion by stimulating hypothalamus-pituitary gland-adrenal cortex axis. Anti-nociceptive effect is achieved by Anti-inflammatory mechanism and it works similar to anti-nociceptive effect of the acupuncture acting on central and peripheral nociceptive transduction system. The Bee Venom therapy could cause severe side effect, for example, hypersensitivity and anaphylaxis, injury to central nerve system and cardiovascular system, peripheral blood system, and renal dysfunction. Conclusions : With its Anti-inflammatory and Anti-nociceptive mechanism, Bee Venom therapy is considered that has good effects to autoimmune disease, chronic inflammation of various musculo-skeletal disease and various pain syndrome. But the clinician must be careful for its side effects.