스코폴라민으로 기억손상을 일으킨 알츠하이머 동물모델에서 Choline Alfoscerate와 Memantine의 기억력 개선 효과

Effects of Choline Alfoscerate and Memantine on Memory Improvement of Scopolamine-induced Memory Impairment animal Model of Alzheimer’s Disease

Choline alfoscerate (choline alf.) is known to be effective in restoring damaged neurons and increasing acetylcholine (ACh) release between synapses. Memantine is known to be neuroprotective by blocking intracellular entry of excess Ca2+ ion. Hence, choline alf. and memantine could be used in combination to improve symptoms of Alzheimer’s disease (AD) by taking advantages of different complementary mechanisms. In this study, we performed ‘water-maze test’ to measure the efficacy of choline alf. and memantine on memory improvement of AD animal models by individual or combined administration. Memory impaired AD animal model was prepared by intraperitoneal (IP) administration of scopolamine (1 mg/ kg). Scopolamine was injected 30 minutes prior to the administration of choline alf. or memantine, then choline alf. (83.3 mg/ kg) or memantine (2.08 mg/kg) were orally administrated 3 hours before the behavioral experiments. The significant improvement in ‘escape latency’ and ‘platform crossing’ were observed in all groups except memantine administrated group. Whereas, the significant improvement in ‘time-in-target-quadrant’ was measured only in the co-administration group of choline alf. and memantine. The results of present study claim that co-administration of choline alf. and memantine is more effective in the improvement of memory impairment than the individual administration of choline alf. or memantine.