우유에서의 클로람페니콜 잔류 소실 양상

Residue depletion profile of chloramphenicol in milk

The residue depletion profile of chloramphenicol from milk was studied after intramuscular injection (IM) milking cow. The drug was administered as a single dose of 10 mg chloramphenicol per kg (body weight) twice a day for 3 consecutive days. Milks were collected before, during and after treatment. The chloramphenicol concentrations in milk were quantified by liquid chromatography-tandem mass spectrometry. Chloramphenicol concentration measured on the first day after the last dose peaked at 313.6 ng/g in milk. The drug residual levels were declined gradually, 0.4 ng/g in milk detected at 5 days after the final dose. The chloramphenicol residue levels in milk dropped to below the EU minimum required performance limit (EU MRPL 0.3 ng/g) on the 6th day of withdrawal of the drug.