인간 기도 상피세포에서 MUC5AC 뮤신 유전자 발현 및 생성에 대한 코니페린 등 흰털오가피 유래 천연물의 영향
Effects of natural products derived from Acanthopanax divaricatus var. albeofructus including coniferin on gene expression and production of MUC5AC mucin from human airway epithelial cells
- 대한약학회
- 약학회지
- 제62권 제2호(2018년)
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2018.03118 - 125 (8 pages)
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DOI : 10.17480/psk.2018.62.2.118
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We investigated whether coniferin, tortoside A, eleutheroside E or salvadoraside derived from Acanthopanax divaricatus var. albeofructus affects airway MUC5AC mucin gene expression and production induced by epidermal growth factor(EGF) from NCI-H292 cells. Cells were pretreated with each agent for 30 min and then stimulated with EGF for 24h. The four compounds inhibited the gene expression and production of MUC5AC mucin from NCI-H292 cells. This result suggests that the four compounds can inhibit the production and gene expression of mucin induced by EGF, through directly acting on airway epithelial cells.
서론 (Introduction)
실험 방법 (Experimental Methods)
실험 결과 (Results)
고 찰 (Discussion)
결 론 (Conclusion)
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