급성 안면부 통증모델에서 한약재료(용규, 포공영, 마치현, 토복령) 추출물의 통증조절효과

Anti－nociceptive effects of herb extract (Solanum nigrum L., Taraxacum platycarpum, Portulaca oleracea L., Smilax china) on acute orofacial pain in rats

Solanum nigrum L., Taraxacum platycarpum, Portulacea oleracea L., and Smilax china are natural products which have an antibiotic effect. They are known for being anti－oxidant, anti－ cancer, anti－nociceptive and detoxification in effect. In oriental medical science they are renowned for protecting kidney and urinary functions. However, the study of influence on relieving inflammatory orofacial pain is insufficient. So, this study deals with influence on orofacial pain control. Experimental 7 to 8－week－old male Sprague－Dawley rats weighing 240∼280g were used. In order to induce acute orofacial pain, 50 μl formalin (5%) was injected under the vibrissapad of the rats. The rats were divided into 6 groups (n=3); formalin, formalin after distilled water (vehicle) or 4 herb extracts ( T. platycarpum, S. nigrum L., P. oleracea L and S. china ). The number of reactive behavioral re-sponses including rubbing or scratching of the facial region was recorded for 9 successive 5－min intervals following formalin injection. Inflammatory orofacial pain was substantially reduced in the 4 herb extracts compared to the control group (vehicle). The pain was reduced in order of ( T. platy-carpum, S. nigrum L., P. oleracea L and S. china ). According to the results, the 4 herb extracts can be considered as potential medicine for lessening acute inflammatory pain in orofacial area.